Blood Platelets in Tissue Regeneration: Narrative Review

Background: The growing multidisciplinary tissue engineering field aims to regenerate, enhance, or replace damaged tissue in an efficient manner in a plethora of conditions linked to trauma, disease, and senescence. To ensure that tissue engineering methods are widely available in clinical settings, they need to be modified to make them promptly available and relatively easy to use in daily clinical routines. Therefore, all steps from preparation to application must be shortened and optimized to be practical, and the implementation must be realistic. The overall aim is to develop platelet concentrates of natural origin close to patients and to accelerate the application process in a way that is financially sustainable for both patients and the National Health System.

Discussion: This semi-systematic review describes and compares the methods used to obtain these materials and exploit their properties and possible uses in personalized treatments. Platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and their derivatives have been employed in a wide array of medical fields for soft-tissue regeneration.

Conclusions: The results of this systematic review highlight the positive effects of platelets contained in PRF compared to PRP in wound healing and after platelet-based regenerative therapy for the management of soft tissue defects found in wound care fields.

Keywords: Platelet-Rich Fibrin, Liquid Fibrinogen, Platelet Concentrate, Platelets, Leukocytes, Prp, Low-Speed Centrifuge,Tissue Regeneration.